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Chemical analysis of antibiotic residues in food / edited by Jian Wang, James D. MacNeil, Jack F. Kay.

Wang, Jian, 1969- (Added Author). MacNeil, James D. (Added Author). Kay, Jack F. (Added Author).
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Electronic resources

Subject: Veterinary drug residues > Analysis.
Antibiotic residues > Analysis.
Food of animal origin > Safety measures.
Anti-Bacterial Agents > analysis.
Chemistry Techniques, Analytical > methods.
Drug Residues.
Food Safety.
Genre: Electronic books.
Electronic book.

Record details

  • ISBN: 9781118067208
  • ISBN: 1118067207
  • ISBN: 9781118067185
  • ISBN: 1118067185
  • ISBN: 1283332086
  • ISBN: 9781283332088
  • Physical Description: 1 online resource (xxi, 353 pages) : illustrations.
  • Publisher: Hoboken, N.J. : Wiley & Sons, ©2012.

Content descriptions

Bibliography, etc. Note: Includes bibliographical references and index.
Formatted Contents Note: Antibiotics : groups and properties / Philip T. Reeves -- Pharmacokinetics, distribution, bioavailability, and relationship to antibiotic residues / Peter Lees and Pierre-Louis Toutain -- Antibiotic residues in food, drinking water, and food safety regulations / Kevin J. Greenlees, Lynn G. Friedlander, and Alistair Boxall -- Sample preparation : extraction and clean-up / Alida A.M. (Linda) Stolker and Martin Danaher -- Bioanalytical screening methods / Sara Stead and Jacques Stark -- Chemical analysis : quantitative and confirmatory methods / Jian Wang and Sherri B. Turnipseed -- Single residue quantitative and confirmatory methods / Jonathan Tarbin [and others] -- Method development and method validation / Jack F. Kay and James D. MacNeil -- Measurement uncertainty / Jian Wang [and others] -- Quality assurance and quality control / Andrew Cannavan, Jack Kay, and Bruno Le Bizec.
Contents note continued: 7.2.3. Conclusions -- 7.3. Ceftiofur and Desfuroylceftiofur -- 7.3.1. Background -- 7.3.2. Analysis Using Deconjugation -- 7.3.3. Analysis of Individual Metabolites -- 7.3.4. Analysis after Alkaline Hydrolysis -- 7.3.5. Conclusions -- 7.4. Chloramphenicol -- 7.4.1. Background -- 7.4.2. Analysis by GC-MS and LC-MS -- 7.4.3. Investigation into the Possible Natural Occurrence of CAP -- 7.4.4. Analysis of CAP in Herbs and Grass (Feed) Using LC-MS -- 7.4.5. Conclusions -- 7.5. Nitrofurans -- 7.5.1. Background -- 7.5.2. Analysis of Nitrofurans -- 7.5.3. Identification of Nitrofuran Metabolites -- 7.5.4. Conclusions -- 7.6. Nitroimidazoles and Their Metabolites -- 7.6.1. Background -- 7.6.2. Analysis -- 7.6.3. Conclusions -- 7.7. Sulfonamides and Their N4-Acetyl Metabolites -- 7.7.1. Background -- 7.7.2. N4-Acetyl Metabolites -- 7.7.3. Analysis -- 7.7.4. Conclusions -- 7.8. Tetracyclines and Their 4-Epimers -- 7.8.1. Background -- 7.8.2. Analysis -- 7.8.3. Conclusions -- 7.9. Miscellaneous -- 7.9.1. Aminoglycosides -- 7.9.2. Compounds with Marker Residues Requiring Chemical Conversion -- 7.9.2.1. Florfenicol -- 7.9.3. Miscellaneous Analytical Issues -- 7.9.3.1. Lincosamides -- 7.9.3.2. Enrofloxacin -- 7.9.4. Gaps in Analytical Coverage -- 7.10. Summary -- Abbreviations -- References -- 8. Method Development and Method Validation / James D. MacNeil -- 8.1. Introduction -- 8.2. Sources of Guidance on Method Validation -- 8.2.1. Organizations that Are Sources of Guidance on Method Validation -- 8.2.1.1. International Union of Pure and Applied Chemistry (IUPAC) -- 8.2.1.2. AOAC International -- 8.2.1.3. International Standards Organization (ISO) -- 8.2.1.4. Eurachem -- 8.2.1.5. VICH -- 8.2.1.6. Codex Alimentarius Commission (CAC) -- 8.2.1.7. Joint FAO/WHO Expert Committee on Food Additives (JECFA) -- 8.2.1.8. European Commission -- 8.2.1.9. US Food and Drug Administration (USFDA) -- 8.3. Evolution of Approaches to Method Validation for Veterinary Drug Residues in Foods -- 8.3.1. Evolution of "Single-Laboratory Validation" and the "Criteria Approach," -- 8.3.2. Vienna Consultation -- 8.3.3. Budapest Workshop and the Miskolc Consultation -- 8.3.4. Codex Alimentarius Commission Guidelines -- 8.4. Method Performance Characteristics -- 8.5. Components of Method Development -- 8.5.1. Identification of "Fitness for Purpose" of an Analytical Method -- 8.5.2. Screening versus Confirmation -- 8.5.3. Purity of Analytical Standards -- 8.5.4. Analyte Stability in Solution -- 8.5.5. Planning the Method Development -- 8.5.6. Analyte Stability during Sample Processing (Analysis) -- 8.5.7. Analyte Stability during Sample Storage -- 8.5.8. Ruggedness Testing (Robustness) -- 8.5.9. Critical Control Points -- 8.6. Components of Method Validation -- 8.6.1. Understanding the Requirements -- 8.6.2. Management of the Method Validation Process -- 8.6.3. Experimental Design -- 8.7. Performance Characteristics Assessed during Method Development and Confirmed during Method Validation for Quantitative Methods -- 8.7.1. Calibration Curve and Analytical Range -- 8.7.2. Sensitivity -- 8.7.3. Selectivity -- 8.7.3.1. Definitions -- 8.7.3.2. Suggested Selectivity Experiments -- 8.7.3.3. Additional Selectivity Considerations for Mass Spectral Detection -- 8.7.4. Accuracy -- 8.7.5. Recovery -- 8.7.6. Precision -- 8.7.7. Experimental Determination of Recovery and Precision -- 8.7.7.1. Choice of Experimental Design -- 8.7.7.2. Matrix Issues in Calibration -- 8.7.8. Measurement Uncertainty (MU) -- 8.7.9. Limits of Detection and Limits of Quantification -- 8.7.10. Decision Limit (CCα) and Detection Capability (CCβ) -- 8.8. Significant Figures -- 8.9. Final Thoughts -- References -- 9. Measurement Uncertainty / Rick Fedeniuk -- 9.1. Introduction -- 9.2. General Principles and Approaches -- 9.3. Worked Examples -- 9.3.1. EURACHEM/CITAC Approach -- 9.3.2. Measurement Uncertainty Based on the Barwick-Ellison Approach Using In-House Validation Data -- 9.3.3. Measurement Uncertainty Based on Nested Experimental Design Using In-House Validation Data -- 9.3.3.1. Recovery (R) and Its Uncertainty [u(R)] -- 9.3.3.2. Precision and Its Uncertainty [u(P)] -- 9.3.3.3. Combined Standard Uncertainty and Expanded Uncertainty -- 9.3.4. Measurement Uncertainty Based on Inter-laboratory Study Data -- 9.3.5. Measurement Uncertainty Based on Proficiency Test Data -- 9.3.6. Measurement Uncertainty Based on Quality Control Data and Certified Reference Materials -- 9.3.6.1. Scenario A: Use of Certified Reference Material for -- Estimation of Uncertainty -- 9.3.6.2. Scenario B. Use of Incurred Residue Samples and Fortified Blank Samples for Estimation of Uncertainty -- References -- 10. Quality Assurance and Quality Control / Bruno Le Bizec -- 10.1. Introduction -- 10.1.1. Quality---What Is It-- 10.1.2. Why Implement a Quality System-- 10.1.3. Quality System Requirements for the Laboratory -- 10.2. Quality Management -- 10.2.1. Total Quality Management -- 10.2.2. Organizational Elements of a Quality System -- 10.2.2.1. Process Management -- 10.2.2.2. Quality Manual -- 10.2.2.3. Documentation -- 10.2.3. Technical Elements of a Quality System -- 10.3. Conformity Assessment -- 10.3.1. Audits and Inspections -- 10.3.2. Certification and Accreditation -- 10.3.3. Advantages of Accreditation -- 10.3.4. Requirements under Codex Guidelines and EU Legislation -- 10.4. Guidelines and Standards -- 10.4.1. Codex Alimentarius -- 10.4.2. Guidelines for the Design and Implementation of a National Regulatory Food Safety Assurance Program Associated with the Use of Veterinary Drugs in Food-Producing Animals -- 10.4.3. ISO/IEC 17025:2005 -- 10.4.4. Method Validation and Quality Control Procedures for Pesticide Residue Analysis in Food and Feed (Document SANCO/10684/2009) -- 10.4.5. EURACHEM/CITAC Guide to Quality in Analytical Chemistry -- 10.4.6. OECD Good Laboratory Practice -- 10.5. Quality Control in the Laboratory -- 10.5.1. Sample Reception, Storage, and Traceability throughout the Analytical Process -- 10.5.1.1. Sample Reception -- 10.5.1.2. Sample Acceptance -- 10.5.1.3. Sample Identification -- 10.5.1.4. Sample Storage (Pre-analysis) -- 10.5.1.5. Reporting -- 10.5.1.6. Sample Documentation -- 10.5.1.7. Sample Storage (Post-reporting) -- 10.5.2. Analytical Method Requirements -- 10.5.2.1. Introduction -- 10.5.2.2. Screening Methods -- 10.5.2.3. Confirmatory Methods -- 10.5.2.4. Decision Limit, Detection Capability, Performance Limit, and Sample Compliance -- 10.5.3. Analytical Standards and Certified Reference Materials -- 10.5.3.1. Introduction -- 10.5.3.2. Certified Reference Materials (CRMs) -- 10.5.3.3. Blank Samples -- 10.5.3.4. Utilization of CRMs and Control Samples -- 10.5.4. Proficiency Testing (PT) -- 10.5.5. Control of Instruments and Methods in the Laboratory -- 10.6. Conclusion -- References.
Summary: An insightful exploration of the key aspects concerning the chemical analysis of antibiotic residues in food The presence of excess residues from frequent antibiotic use in animals is not only illegal, but can pose serious health risks by contaminating products for human consumption such as meat and milk. Chemical Analysis of Antibiotic Residues in Food is a single-source reference for readers interested in the development of analytical methods for analyzing antibiotic residues in food. It covers themes that include quality assurance and quality control, antibiotic chemical pro.
Source of Description Note: Print version record.
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