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Nutritional genomics : discovering the path to personalized nutrition / edited by James Kaput and Raymond L. Rodriguez.

Kaput, James, 1952- (Added Author). Rodriguez, Raymond L. (Added Author).
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  • 1 of 1 copy available at Island Libraries.

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Library Call Number Barcode Location Status Due Date
Robertson Library RA784.N855 2006 37348006896427 STACKS Available -
Subject: Nutrition.

Record details

  • ISBN: 9780471683193
  • ISBN: 0471683191
  • Physical Description: xxv, 469 p. : ill. ; 25 cm.
  • Publisher: Hoboken, N.J. : Wiley-Interscience, c2006.

Content descriptions

Bibliography, etc. Note: Includes bibliographical references and index.
Formatted Contents Note: Part 1: An Introduction and Overview of Nutritional Genomics: Application to Type 2 Diabetes and International Nutrigenomics / Jim Kaput -- Understanding T2DM: The Current View of T2DM and Treatment Options -- Understanding T2DM: Begin Before Conception -- Understanding T2DM: Genetic Complexity -- Understanding T2DM: QTLs in Humans -- Understanding T2DM: From Birth Onward -- Understanding T2DM: Metabolomics -- Understanding T2DM: Environmental Influences -- Understanding T2DM: Environment Is More Than Diet -- Understanding T2DM: Data Acquisition and Analyses -- Bioinformatics and Biocomputation -- Converting Science into Practice -- Research Ethics and Genetic Privacy -- Health Disparities -- Public and International Policies -- Part 2: The Pursuit of Optimal Diets: A Progress Report / Walter C. Willett -- Considerations in Defining an Optimal Diet -- Dietary Fat and Specific Fatty Acids -- Carbohydrates -- Protein -- Vegetables and Fruits -- Calcium and Dairy Products -- Salt and Processed Meats -- Alcohol -- Vitamin and Mineral Supplements -- Potential Impact of Optimal Diet and Life-Style Changes -- Part 3: Gene-Environment Interactions: Defining the Playfield / Jose M. Ordovas, Dolores Corella -- Genetic Variability -- How to Detect Genetic Variability -- What to Analyze -- Environmental Factors -- Gene-Environment Interactions: Focus on Diet -- Common Genetic Variants and Gene-Diet Interactions Modulating Plasma Lipoprotein Concentrations -- Gene-Microorganisms Interactions -- The Microbiome (Microbiota) -- Part 4: Metabolomics: Bringing Nutrigenomics to Practice in Individualized Health Assessment / J. Bruce German, Cora J. Dillard, S. Luke Hillyard, Matthew C. Lange, Jennifer T. Smilowitz, Robert E. Ward, Angela M. Zivkovic -- Opportunities for Foods and Health -- Nutrigenomics -- Metabolomics -- Genomics -- Metabolome Assembly and Annotation -- Bioinformatics: Knowledge Management from Genomics and Metabolomics to Health Assessment -- Part 5: Genetic and Molecular Buffering of Phenotypes / John L. Hartman IV -- Examples of Buffering -- Experimental Concepts for Genetic Buffering Analysis -- Experimental Platforms for Global Genetic Interaction Analysis -- Part 6: Gene-Gene Epistasis and Gene-Environment Interactions Influence Diabetes and Obesity / Sally Chiu, Adam L. Diament, Janis S. Fisler, Craig H. Warden -- Gene-Gene and Gene-Environment Interactions -- Epistasis and Gene-Environment Interactions in Obesity and Diabetes -- Animal Models for Detecting Gene Interactions -- Gene-Gene Interaction in Obesity and Diabetes -- Dietary Fat in Obesity and Diabetes -- Maternal Effects -- Future Directions and Conclusion -- Part 7: Nutrients and Gene Expression / Gertrud U. Schuster -- SREBPs and ChREBP: Transcription Factors Influenced by Dietary Lipids and Glucose -- Superfamily of Nuclear Receptors -- Nuclear Receptors: Structure and Function -- Nuclear Receptors as Metabolic Sensor -- Vitamins -- Phytoestrogens: Nutrients Mimicking Estrogens –- Polymorphisms --
Part 8: Green Tea Polyphenols and Cancer Prevention / Shangqin Guo, Gail Sonenshein -- Green Tea and Cancer Epidemiology -- Animal Models -- Mechanisms of Green Tea Action: Molecular Signaling Pathways and Gene Targets -- Clinical Studies and the Promise of Tea in Combinatorial Therapy -- Future Directions and Conclusion -- Part 9: Molecular Mechanisms of Longevity Regulation and Calorie Restriction / Su-Ju Lin -- A Conserved Longevity Factor, Sir2 -- Molecular Mechanisms of Calorie Restriction -- Role of NAD/NADH Ratio in Aging and Human Diseases -- Possible CR Mimetics - Small Molecules That Regulate Sir2 Activity -- Molecular Targets of Sir2 Proteins in Mammals -- A Possibly Conserved Longevity Pathway -- Applications to Nutritional Genomics -- Part 10: Maternal Nutrition: Nutrients and Control of Expression / Craig A. Cooney -- Methyl Metabolism -- DNA Methylation, Epigenetics, and Imprinting -- Endogenous Retroviruses and Genome Integrity -- Epigenetics and Nutrition Can Greatly Modulate Genetic Predispositions -- Yellow Mouse Models of Epigenetic Regulation -- A Variety of Maternal Effects Seen in Mice -- Rat Models of Maternal Effects Leading to Diabetes -- Maternal Effects on Memory and Aging -- Epigenetic Effects in Foxes -- Epigenetic Effects Related to Reproduction in Humans -- Nutrients and Compounds That May Affect Early Development and Epigenetics -- Part 11: Nutrient-Gene Interactions Involving Soy Peptide and Chemopreventive Genes in Prostate Epithelial Cells / Mark Jesus M. Magbanua, Kevin Dawson, Liping Huang, Wasyl Malyj, Jeff Gregg, Alfredo Galvez, Raymond L. Rodriguez -- Lunasin Structure and Function -- Lunasin Treatment of Prostate Cancer and Gene Expression Profiling -- Lunasin-Induced Gene Expression Profiles -- Genes for Apoptosis -- Genes Involved in Suppression of Cell Proliferation -- Mitotic Checkpoint Genes -- Genes Involved in Protein Degradation -- Connexin 43 Gene for the Gap Junction Protein -- Target Verification Using RT-PCR -- Part 12: Enzymes Lose Binding Affinity (Increased Km) for Coenzymes and Substrates with Age: A Strategy for Remediation / Bruce N. Ames, Jung H. Suh, Jiankang Liu -- Remediation by High B Vitamin Intake of Variant Enzymes with Poor Binding Affinity (Km) for Coenzymes -- Deformation of Proteins in Mitochondria with Aging -- Nonmitochondrial Enzymes that are Deformed with Age -- Part 13: Dietary and Genetic Effects on Atherogenic Dyslipidemia / Ronald M. Krauss, Patty W. Siri -- LDL Represents a Heterogeneous Population of Particles -- LDL Subclasses Influenced by Genes and the Environment -- Part 14: Genistein and Polyphenols in the Study of Cancer Prevention: Chemistry, Biology, Statistics, and Experimental Design / Stephen Barnes, David B. Allison, Grier P. Page, Mark Carpenter, Gary L. Gadbury, Sreelatha Meleth, Pamela Horn-Ross, Helen Kim, Coral A. Lamartinere -- Diet and Cancer -- Chemistry of the Polyphenols -- Uptake, Distribution, Metabolism, and Excretion of Polyphenols -- Polyphenols and Cancer Prevention -- Mechanisms of Action of Polyphenols -- Assessing Events Leading to Cancer: Low-Dimensional Approaches -- Statistical Consequences of High-Dimensional Approaches -- High-Dimensional Systems and the Importance of the False Discovery Rate -- DNA Microarray Analysis: High-Dimensional Research into Gene Expression -- Proteomics Analysis: An Even Bigger Challenge -- Statistical Problems with Fold-Change in DNA Microarray and Proteomics Analyses -- Design in Experiments Involving DNA Microarray and Proteomics Analysis -- The Design -- Role of the Computer in High-Dimensional Analysis --
Part 15: Susceptibility to Exposure to Heterocyclic Amines from Cooked Food: Role of UDP-Glucuronosyltransferases / Michael A. Malfatti, James S. Felton -- Genetic Susceptibility -- UDP-Glucuronosyltransferase -- UDP-Glucuronosyltransferase Biochemistry -- UDP-Glucuronosyltransferase Gene Structure -- Substrate Specificity and Selectivity -- Tissue Distribution of UPD-Glucuronosyltransferase -- Gene Regulation -- Genetic Variation -- UPD-Glucuronosyltransferase and Cancer Susceptibility -- Heteroyclic Amine Carcinogens in Food -- Carcinogenicity of PhIP -- Metabolism of PhIP -- UDP-Glucuronosyltransferase and PhIP Risk Susceptibility -- Part 16: The Informatics and Bioinformatics Infrastructure of a Nutrigenomics Biobank / Warren A. Kibbe -- Next Generation Biobanks -- Intended Audience for this Chapter -- Assumptions, Use Cases, and Design Criteria -- Regulatory and Policy Environment -- HIPAA - Health Insurance Portability and Accountability Act of 1996 -- GMPs, GLPs, and GCPs -- Funding of Biobanks -- Biobanking in Clinical Trials -- Data Standards/Semantic Interoperability -- Other Standards Bodies: CDISC -- Informatics Infrastructure -- System Architecture -- Separation of the Clinical Trial/Patient Identity Management from the Genotype/Phenotype Repository -- Database Architecture/Data Modeling -- Design Practices -- Part 17: Biocomputation and the Analysis of Complex Data Sets in Nutritional Genomics / Kevin Dawson, Raymond L. Rodriguez, Wayne Chris Hawkes, Wasyl Malyj -- Nutritional Genomics: Part of High-Throughput Biology -- Gene Expression Arrays -- Proteomics and Metabolomics Data -- Sources of Complexity in Nutritional Genomics -- Data Sets in Nutritional Genomics -- Level of Complexity in Gene Expression Experiments -- Dimensionality Reduction Methods -- Case Study (Microarray Experiment of a Dietary Intervention) -- Part 18: Cultural Humility: A Contribution to Health Professional Education in Nutrigenomics / Melanie Tervalon, Erik Fernandez -- Cultural Humility -- Summary -- Goals and Objectives: Curriculum Content -- Goals and Objectives: Curriculum Design -- Curriculum Structure and Content: Diactics, Small Groups, and Videotaping -- The Teaching Staff -- Evaluation -- Part 19: Nutrients and Norms: Ethical Issues in Nutritional Genomics / David Castle, Cheryl Cline, Abdallah S. Daar, Charoula Tsamis, Peter A. Singer -- Proactive Ethics and Nutritional Genomics -- Claims of Health Benefits Arising from Nutrigenomics -- Managing Nutrigenomics Infromation -- Methods for Delivering Nutrigenomics Services -- Nutrigenomics Products -- Access to Nutrigenomics.
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